Take on your day, without losing your mind: The Benefits of Red Reishi

Take on your day, without losing your mind: The Benefits of Red Reishi

Adaptogens, like Red Reishi (Ganoderma lucidum), are metabolic regulators which increase our ability to handle and adapt to stress. Being classified as an adaptogen, the important medicinal compounds found in Vibe Mushroom’s Red Reishi extract have been shown to increase resistance to daily stress, decrease sensitivity to daily stressors, improve relaxation, and promote increased sleep quality.

Vibe’s pharmaceutical-grade Red Reishi has the industry’s highest levels of bioactive compounds including polysaccharides (e.g., Beta-glucans), terpenoids and triterpenoids (e.g., Ganoderic acids), fatty acids, proteins, and glycopeptides. It is these compounds which provide several adaptogenic benefits you can feel, including:

  • Increased cognition
  • Neuroprotection
  • Increased motivation
  • Reduced anxiety
  • Reductions in depressive symptoms
  • Increased feelings of relaxation
  • Improved recovery from physical and mental stress
  • Anti-inflammatory actions
  • Immune system optimization

Since Red Reishi serves as a regulator of biological activities, it is considered one of the most important traditional medicinal mushrooms and one of the most effective adaptogens found in nature.

Among the terpenoid class, the most represented in Red Reishi are Ganoderic acids which have been reported to treat symptoms of stress including inflammation, depression and anxiety, sleep disorders, and unexplained fatigue. Beyond its adaptogenic benefits, Red Reishi has also been shown to improve bone disorders, cancer outcomes, epileptic episodes, diabetes, dyslipidemia, cardiovascular problems, and immune-related disorders. 

RED REISHI: The Fatigue Fighter

A large-scaled study conducted on 132 volunteers with chronic fatigue syndrome reported that long term Reishi supplementation (2 months or greater) led to significant improvements in fatigue and well-being with no adverse effects.

RED RESIHI: The Chill Pill

When taken before bedtime, Red Reishi promotesedation, relaxation, sleepand reductions in restlessness. The tranquilizing effect of Reishi was recorded in “Shennong's herbal classic” as early as the first century BC and currently in the Chinese Pharmacopoeia. Recently, it was reported that Reishi improved the sleep of patients with insomnia and other mental disorders, and it has been shown to reduce the time it takes to get to sleep while increasing the time we stay asleep. 

The science behind how Reishi chills you out:

Various neurotransmitters, including GABA, serotonin (5-HT,) norepinephrine, and dopamine, affect different brain nuclei to regulate the switch between wakefulness and sleep. Reishi promotes sleep, decreased wakefulnessand reduced restlessness via 2 known mechanisms:

  1. The sedative and hypnotic effects of Reishi extract involve benzodiazepine receptors in the brain, the target of traditional sedative and hypnotic drugs.
  2. Reishi promotes sleep through increases in 5-HT by positively interacting with the gut microbiome. 5-HT or serotonin is important in sleep regulation. 5-HT deficiency has been shown to increase nighttime wakefulness, restlessness, and decreased sleep time.


For best results, take 1 to 3 grams daily (0.5to 1.5 tsp or 2 to 6capsules), taken all at once in the morning, split up throughout the day, or taken 30-60 minutes before bed. If you use a full 3 grams daily, split it into 3 x 1-gram doses and take throughout the day. With our powered format, you can mix it directly into your coffee, tea, yogurt, greens, or smoothies. Because Vibe’s Red Reishi is pharmaceutical-grade potency, the concentrated Ganoderic acids make it taste bitter. Many people enjoy its bitterness, but bitter may not be your thing. If this is the case, we suggest splitting doses or using our capsules.


Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D'Ursi AM, Campiglia P, Rodriquez M. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury. Pharmaceuticals (Basel). 2020 Aug 29;13(9):224.

Wachtel-Galor S., Yuen J., Buswell J.A., Benzie I.F.F. Ganoderma Lucidum (Lingzhi or Reishi) Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Taylor and Francis Group; Milton Park, UK: 2011.

Chu T.T., Benzie I.F., Lam C.W., Fok B.S., Lee K.K., Tomlinson B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): Results of a controlled human intervention trial. Br. J. Nutr. 2012;107:1017–1027.

Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021).

Yuen J.W., Gohel M.D. Anticancer effects of Ganoderma lucidum: A review of scientific evidence. Nutr. Cancer. 2005;53:1117

Wu Y.L., Han F., Luan S.S., Ai R., Zhang P., Li H., Chen L.X. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects. J. Agric. Food Chem. 2019;67:51475158.

Lu S.Y., Peng X.R., Dong J.R., Yan H., Kong Q.H., Shi Q.Q., Li D.S.,Zhou L., Li Z.R., Qiu M.H. Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities. Fitoterapia. 2019;134:5864.

Bishop, K. S. et al. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 114, 5665 (2015).

Cuong V.T., Chen W., Shi J., Zhang M., Yang H., Wang N., Yang S., Li J., Yang P., Fei J. The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans. Exp. Gerontol. 2019;117:99105.

Wang J., Cao B., Zhao H., Feng J. Emerging Roles of Ganoderma Lucidum in Anti-Aging. Aging Dis. 2017;8:691707.

Bishop K.S., Kao C.H.J., Xu Y., Glucina M.P., Paterson R.R.M., Ferguson L.R. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry. 2015;114:5665.

Liang C., Tian D., Liu Y., Li H., Zhu J., Li M., Xin M., Xia J. Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. Eur. J. Med. Chem. 2019;174:130141.

Zhao X.R., Zhang B.J., Deng S., Zhang H.L., Huang S.S., Huo X.K., Wang C., Liu F., Ma X.C. Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum. Phytochem. Lett. 2016;16:8791.

Liu Z., Xing J.,Zheng S., Bo R., Luo L., Huang Y., Niu Y., Li Z., Wang D., Hu Y., et al. Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response. Carbohydr. Polym. 2016;142:141148.

Baby S., Johnson A.J., Govindan B. Secondary metabolites from ganoderma. Phytochemistry. 2015;114:66101.

Li L., Wang H.H., Nie X.T., Jiang W.R., Zhang Y.S. Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. J.Cell. Biochem. 2018;120:23702381.

Kladar N.V., Gavarić N.S., Božin B.N. Ganoderma: Insights into anticancer effects. Eur. J. Cancer Prev. 2016;25:462471.

Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8.

Cui XY, Cui SY, Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH. Extract of Ganoderma lucidum prolongs sleep time in rats.J Ethnopharmacol. 2012 Feb 15;139(3):796-800.

Chu QP, Wang LE, Cui XY, Fu HZ, Lin ZB, Lin SQ, Zhang YH. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. Pharmacol Biochem Behav. 2007 Apr;86(4):693-8.

Lee I., Ahn B., Choi J., Hattori M., Min B., Bae K. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic Med. Chem. Lett. 2011;21:66036607.
Back to blog